While 5-MeO-DMT shows promise as a therapeutic tool, the drug has been used for centuries as a tool for personal and spiritual growth. In fact, a recent survey from Davis and Barsuglia found that most users of 5-MeO-DMT used the drug for spiritual exploration and reported intense mystical-type experiences, including ego death.
This experience is often described in positive terms—even if it was terrifying at the time. Many see it as a process of death and rebirth followed by lasting self-improvements, including mental clarity, increased motivation, enhanced awareness, joy in living, and a sense of inner peace. Some have also had enlightenment experiences, characterized by a sense of inseparability from the universe or of being “all that exists.” Often, these experiences come in waves or reactivations over the following days or weeks.
Being forced to let go of the ego is precisely what draws many people to 5-MeO-DMT. The dissolution experience can impart an understanding and acceptance of mortality that helps people overcome the fear of death. It can also heal past trauma, negative behaviors, and habitual negative thought patterns.
One group of 5-MeO-DMT ‘practitioners’ have also reported that there are a number of specific integration and grounding techniques to increase the potential for growth. These include acupuncture, massage, physical exercise, certain foods, and even just talking to others. Interestingly, they advise against meditation because it could end up prolonging the grounding/integration period by triggering additional reactivations.

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